Dian Sastro Wardoyo started his career in the entertainment industry in 1996, as the first champion in the event, held a magazine cover girl GIRL. He cited as an icon of national awakening movie with colleagues in the film AADC, Nicholas Saputra. His first film The Shooting Star (2000), by Rudi Sujarwo, indie circulated on college campuses and is not showing in theaters. In the film Dian compete acting with Marcella Zalianty, Garry Isaac and Indra Birowo. The next movie in 2001, Whispering Sand won acting by Christine Hakim, Slamet Rahardjo and Didi Petet. Through this film, Dian was awarded the best female actor at the Singapore International Film Festival (2002) and the Asian Film Festival in Deauville, France (2002).
Dian also been a Super Millionaire quizmaster 3 Billion which aired at the quiz. He also starred in the TV series, entitled World Without Koma on RCTI